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Literature summary for 3.4.22.B60 extracted from

  • Leng, Y.P.; Ma, Y.S.; Li, X.G.; Chen, R.F.; Zeng, P.Y.; Li, X.H.; Qiu, C.F.; Li, Y.P.; Zhang, Z.; Chen, A.F.
    L-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia (2018), Br. J. Pharmacol., 175, 1157-1172 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B60

Cloned(Commentary)

Cloned (Comment) Organism
real-time PCR enzyme expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide SID, cathepsin L/V inhibitor SID attenuates vascular inflammation in hyperhomocysteinaemic mice, and SID decreases the number of leukocytes and the expression of interleukin-6, CXCL15 (human IL-8 homologous), and TNF-alpha in the thoracic arteries of hyperhomocysteinaemic mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Mus musculus
-
endothelial cell cathepsin L (human cathepsin V homologue) is increased in the thoracic aorta endothelial cells of hyperhomocysteinaemic mice Mus musculus
-
thorax
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
cathepsin L2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus L-homocysteine induces cathepsin V/L expression, methylation of the promoter region of cathepsin V is decreased following L-homocysteine stimulation up

General Information

General Information Comment Organism
metabolism effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways Mus musculus
physiological function L-homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities Mus musculus